According to reports recently organized by the American Physicists Organization Network, the University of Illinois at Urbana-Champaign developed a wound bandage called "microtubule patch," which contains living cells and can release growth factors to injured tissues according to a given pattern. Stimulate and guide the growth of blood vessels on the wound surface. After one week, blood vessels can grow as microtubules. The related paper will be published as a cover article in the January 2012 issue of Advanced Materials magazine.

This microtube is about 1 cm wide and is made of a layer of hydrogel. Hydrogel consists of two components, one is polyethylene glycol, which has been approved by the U.S. Food and Drug Administration for use as a laxative and pharmaceutical product; the other is alginate methacrylate , is an edible material similar to jelly. Microtubes have good air permeability and allow small molecules to leak out, while micropipes with different thickness can guide the flow of macromolecules such as growth factors. The researchers tested the effect of microtubules on the surface of chicken embryos and removed them one week later. It was found that the microtubule lines formed a new vascular network.

The regeneration of any tissue, such as bone, muscle, or skin, requires the regeneration of large numbers of blood vessels, and one of the major difficulties is the control of the distance between growth factors and new blood vessels. Previously, laboratories had used growth factors embedded in wound-sealing materials to guide blood vessel growth. New research, for the first time, added live cells to the wound patch to release growth factors more persistently and directionally. This is the first demonstration of the ability to use biological materials to control blood vessel growth. Rashid Bache, a professor of electronics and computer engineering at the school, said: “Designing blood vessels in living tissue and writing blood vessels is impossible before.”

The researchers also pointed out that the new type of wound dressing has a wide range of applications, from guiding the growth of blood vessels around the aorta to increasing the blood vessels in scarce blood supply tissue, and also to “normalize” the blood vessels that feed tumors. Cancer drug delivery and the like. If it is possible to promote the growth of new blood vessels in a harmonious manner after surgery, it is expected to reduce the time of scars and wound healing.

Knob Lock

In terms of knobs, there are usually two types of entrances and exits for all types of buildings.One is the key door handle lock.This is a simple door handle that includes an internal lock, which is operated by inserting a key into the lock part.Turning the key can lock and unlock the door, effectively restricting those who have the key from entering the building.Keys are not allowed to be inserted. This type of door handle lock relies on a smaller handle located in the middle of the door handle.Turn this small handle to the left or right to lock or open the door.This type of knob is usually used in the master bedroom or bathroom of a private house. The electronic version of the knob lock has also been widely used.

A key doorknob lock. This is a simple doorknob that includes an internal lock that is operated by inserting a key into the lock component. Turning the key makes it possible to lock and unlock the door, effectively limited access to the building to those who have keys that fit the lock.This is the oldest and most common form of knob lock in the world today.


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